MAM Consortium

MAM Consortium is an industry-wide, nonprofit 501(c)(6) organization with the mission to advance Multi-Attribute Method (MAM) and other LC/MS applications in pharmaceutical and biotechnology companies for product characterization, in-process control, and GMP release and stability testing.

News

Impact story published by FDA: Transitioning a Powerful Analytical Tool into Manufacturing to Improve the Quality of Complex Therapeutics.
USP Biologics Open Forum on MAM: April 28, 2021, 11am - 12pm EDT.

Events

Thursday, June 27, 2024 from 8 am – 9 am PDT

Presentation by Rachel Shi, Genentech: Innovating Mass Spectrometry Approaches for Characterizing Emerging Modality Therapeutics

Thursday, May 9, 2024 from 8 am – 9 am PDT

Presentation by Bingchuan Wei, Genentech: Unveiling Structural-Function Relationship through Hydrogen Deuterium Exchange Coupled with Mass Spectrometry (HDX-MS)

Thursday, April 18, 2024 from 8 am – 9 am PDT

Presentation by Sara Carillo, NIBRT: Characterizing AAV Quality Attributes Using Mass Spectrometry

Friday, February 23, 2024 from 8 am – 9 am PDT

Presentation by by Brian Gfeller, Pfizer: Application of HT-MS to Support Process Analytical Characterization

Thursday, November 30, 2023 from 8 am – 9 am PDT

Presentation by Vamsi Kandhi, Pfizer: A Comprehensive Approach: MAM for Product and Process Understanding

Tuesday, October 24, 2023 from 8 am – 9 am PDT

Presentation by Sarah Rogstad, FDA: The Use of Mass Spectrometry in Therapeutic Protein Biologics License Applications: A Retrospective Review Revisited

Thursday, September 28, 2023 from 8 am – 9 am PDT

Presentation by Brian Gau, Pfizer: Oligonucleotide Mapping via LC-UV-MS/MS to Enable Comprehensive Primary Structure Characterization of mRNA Drug Substanc

Thursday, August 17, 2023 from 8 am – 9 am PDT

Presentation by Jennifer Zhang, Genentech: Enabling MAM for Control System Testing: A Case Study for Commercial Launch Readiness

Thursday, July 27, 2023 from 8 am – 9 am PDT

Presentation by Hirsh Nanda, Janssen: Lab-of-the-Future: A Robotic and Cloud-Based Analytical Pipeline for High-Throughput Characterization of Biologics

Wednesday, June 21, 2023 from 8 am – 9 am PDT

Presentation by Krisztina Radi & Ilker Sen, Protein Metrics: Spotting the Outliers in MAM Runs Automatically with Deep Query and Dashboards

Tuesday, May 30, 2023 from 8 am – 9 am PDT

Presentation by Da Ren, BioTherapeutics Solutions: MAM, An Eight Year Overview

Wednesday, March 22, 2023 from 8 am – 9 am PDT

Presentation by Dan Bach Kristensen, Symphogen: Addressing Missed Cleavages and Chromatographic Peak Tailing/Carry-over in MAM Workflows

Wednesday, February 15, 2023 from 8 am – 9 am PDT

Presentation by Angela Criscuolo and Alexander A. Makarov, Thermo Fisher Scientific: iMAM: MAM on the Intact Protein Level - Measurement of Molecular Elephants and Whales by Orbitrap Mass Spectrometry

Tuesday, December 13, 2022 from 8 am – 9 am PDT

Presentation by Annick Gervais, Eef Dirksen, Thomas Pohl, EFPIA: Regulatory Considerations for the Applications of Multi-Attribute Method by Mass Spectrometry for QC Release and Stability Testing of Biopharmaceuticals

Tuesday, October 25, 2022 from 8 am – 9 am PDT

Presentation by Beth McCoy, Pfizer: Qualification of the Platform Multi-Attribute Method (MAM) at Pfizer

Tuesday, September 20, 2022 from 8 am – 9 am PDT

Presentation by Ying Qing Yu, Waters: Recent Advancements in Peptide MAM: Improvement on Chromatographic Performance for CQA Peptides and New Peak Detection

Thursday, August 18, 2022 from 8 am – 9 am PDT

Presentation by Haichuan Liu, SCIEX: Differentiation of Deamidation Isomers in Biopharmaceutical Modalities for Multi-Attribute Method Using an Alternative Electron-Based Dissociation Approach

Thursday, July 21, 2022 from 8 am – 9 am PDT

Presentation by Professor Sunny Zhou, Northeastern University: Chemo-Enzymatic Approaches for the Analysis of Product Quality Attributes (PQAs)

Friday, June 3, 2022 from 8 am – 9 am PDT

Presentation by Cinzia Stella, Genentech: Online HPLC-HRMS Platform: The Next-Generation Process Analytical Technology Tool for Real-Time Monitoring of Antibody Quality Attributes in Biopharmaceutical Processes

Tuesday, May 3, 2022 from 8 am – 9 am PDT

Presentation by Josh Eckels and Danielle Faivre, LabKey: Skyline and Panorama Support for MAM Analysis

Thursday, April 7, 2022 from 8 am – 9 am PDT

Presentation by Andrew Mahan, Janssen: Comprehensive Characterization of mAbs and Multispecifics with Multiple Technologies, CE, iCIEF-MS, and Novel Alternative Fragmentation

Thursday, January 13, 2022 from 8 am – 9 am PST

Presentation by Pavel Bondarenko, Amgen: Identification of Critical Chemical Modifications and Paratope Mapping by SEC of Stressed Antibody-target Complexes

Friday, December 10, 2021 from 8 am – 9 am PST

Presentation by John Schiel, NIST: Mass Spectrometry as a Disruptive Technology for Emerging Modalities

Monday, November 15, 2021 from 8 am - 9 am PDT

Presentation by Diane McCarthy, US Pharmacopeia: USP Standards to Support Multi-Attribute Methods

Thursday, October 14, 2021 from 8 am - 9 am PDT

Presentation by Adam Evans, Janssen: Multi-Attribute Monitoring from Development to Commercial QC

Monday August 9, 2021 from 8 am - 9 am PDT

Presentation by Mitul Patel, GSK: Incorporating Mass Spectrometry into Analytical Strategies to Early De-risk the mAb Discovery and CMC processes

Friday June 11, 2021 from 8 am - 9 am PDT

Presentation by Silvia Millán Martín, NIBRT: The role of MAM in advancing innovative analytical strategies for biotherapeutics characterization and the benefits of New Peak Detection

Thursday, May 27, 2021 from 8 am - 9 am PDT

Presentation by Rich Rogers, BMS: Mass Spectrometry-Based Process Analytical Technologies for Cell Therapies

Friday April 16, 2021 from 8 am - 9 am PDT

Presentation by Camille Lombard-Banek, NIST: Expending MAM Principles to the Characterization of Cell-based Therapies

Friday December 19, 2020 from 8 am - 9 am PST

Presentation by Yuting Huang, Pfizer: Accelerating Biotherapeutic Development by Automated MAM

Thursday November 19, 2020 from 8 am - 9 am PST

Presentation by Shawn Li, Merck: Transition of Multi-Attribute Method (MAM) to GMP for biotherapeutics

Friday September 25, 2020 from 8 am - 9 am PDT

Presentation by Lucie Manache-Alberici & Cedric Mesmin, Merck Group: Validation of an LC-MS Multi-Attribute Method (MAM) Supporting Biopharma Process Characterization

Friday July 31, 2020 from 8 am - 9 am PDT

Presentation by Yuko Ogata, Just – Evotec Biologics: Automated MAM Sample Preparation

Friday June 19, 2020 from 8 am - 9 am PDT

Presentation by Zhiqi Hao, Genentech: Validation of MAM for QC Lab-of-the-Future

Friday April 3, 2020 from 8 am - 9 am PDT

Presentation by Michael Blank, AbbVie Inc.: Enabling Process Changes to Minimize Disulfide Scrambling Using a Non-Reducing Multi-Attribute Method

Thursday December 5, 2019 from 8 am - 9 am PST

Presentation by Bo Zhai, Janssen R&D: Automated Sequence Variant Analysis and CLD Data Management

Tuesday November 19, 2019 from 9 am - 10 am PST

Presentation by Monica Sadek, Genentech: MAM Instrument Evaluation & Lessons Learned

Tuesday October 22, 2019 from 9 am - 10 am PDT

Presentation by Sarah Rogstad, FDA: Quality Considerations for MAM

Thursday August 22, 2019 from 9 am - 10 am PDT

Presentation by Ben Neely, NIST: QC Benchmarker: a streamlined web application to comprehensively evaluate instrument performance and direct troubleshooting

Thursday July 25, 2019 from 9 am - 10 am PDT

Presentation by Da Ren, Amgen: Strategies and Practices for Implementing Multi-Attribute Method (MAM) in GMP Environment

Thursday May 16, 2019 from 9 am -10 am PDT

Presentation by John Schiel, NIST: Implementing the principles of MAM from NISTmAb to non-originators